Provides sequence-activity relationship analysis for peptides.
Once a dataframe is opened with Datagrok, the column(s) containing peptides are detected automatically. Each amino acid is rendered with a different color based on used monomer library, which helps to visually identify patterns. Clicking on the column header brings up the options to launch peptide-specific tools, such as SAR and others.
Wiki: Structure-Activity Relationship (SAR) is an approach designed to find relationships between chemical structure (or structural-related properties) and biological activity (or target property) of studied compounds.
Peptides SAR is an interactive analysis tool to help identify point mutations and residues that cause major change in
activity. Analysis can be triggered from context menu of a peptide column or from top menu Bio | Analyze | SAR.
You can choose the peptides column, activity column, configure scaling, clustering and other options.
You can read more about the tool in our help section.